Juniper Publishers- Drug Design Open Access Journals

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Sepsis characteristics were highlight in this mini review in order to call attention for a complex, age- independent, acute disease faced suddenly by the human body under infection or traumatic stimuli. It may follow surgical intervention, traumatic accident or exposure to an infectious agent. Timely diagnosis and accurate stratification of the severity of sepsis are needed to understand the molecular mechanisms involved in this pathophysiology and reduce mortality. In order to obtain these achievements follow-up studies need to be conducted in intensive care units under translational research. Keywords: Sepsis, Intensive care unit, Inflammation, Nitric oxide, Acetylcholinesterase Mini Review The high mortality verified worldwide in patients with sepsis in intensive care units (ICU) is a sad...

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Crimean Congo virus that causes hemorrhagic fever belongs to Bunyaviridea family [1] and genus Nairoviridea [2]. First case of this disease was inspected in Tajisktan in 12th century [3] however this disease gained more attention in 1944 when about 200 military officers of Soviet Union died of this infectious disease at the place of Crimea so named as Crimean Congo hemorrhagic fever. Its etiology was studied by inducing fever in psychiatric patients by inoculating them with virus obtained from the blood of CCHF patients. Chumkov and his colleagues first time isolated a prototype of this virus in 1967 in Moscow [4]. This virus has wide geographical distribution and found across middle east, china, southern Europe, Africa and various areas of Asia [2]. CCHFV is a tripatric RNA virus (Three negative RNA strands that codes for three different proteins): S segment codes for nucleoprotein [5], M S...