Juniper Publishers- Drug Design Open Access Journals

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT   Abstract Aim : The aim of this review commentary is to compare measured permeability class versus predicted one using metabolism and partition coefficient values for WHO essential drugs list. Methods : Predicted permeability classes were based on partition coefficient or metabolism. Comparisons were then done against measured permeability classes. Results and discussion : Predictions were close to measured permeability classes for many drugs using all prediction methods using metoprolol coefficients as reference marker and high extraction ratio for high permeability. However, some false negative and false positive predictions were observed. This can lead to wrong permeability classification and hence wrong biopharmaceutics classification (BCS). The best method with least false predictions in the studied compounds was using more than 90% metabolism as indicator o...

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Introduction Advantages of micro emulsion based systems [2] Microemulsions are thermodynamically stable system and the stability allows self-emulsification of the system whose properties are not dependent on the process followed. Microemulsions act as super solvents of drug. The dispersed phase, lipophilic or hydrophilic (oil-in-water, O/W, or water-in-oil, W/O microemulsions) can behave as a potential reservoir of lipophilic or hydrophilic drugs, respectively. The mean diameter of droplets in microemulsions is below 0.22μm; they can be sterilized by filtration. Same microemulsions can carry both lipophilic and hydrophilic drugs. Because of thermodynamic stability, microemulsions are easy to prepare and require no significant energy contribution during preparation. Microemulsions have low viscosity compared to other emulsions. The use of microemulsion as delivery systems can improve t...

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Peptides and bioactive proteins are detected as new therapeutic molecules with changing biological attributes for potential medical claims. With attention to their practical properties, bioactive peptides may be classified as antimicrobial, antihypertensive, opioid, antioxidative and etc. These peptides play a significant identity in human health. Progress of peptide and protein based therapeutic output for human use is growing continually as they carry on to receive an enhancing ratio of support by (US FDA). Peptide based drugs are a significant series of therapeutic agents but their progress into commercial products is often blocked due to their natural physico-chemical and biological instabilities. In this mini review, we characterize the recent methodologies and condition involved in the peptide and protein in industry in the therapeutic products section. Keywords: A...