Juniper Publishers- Drug Design Open Access Journals

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Introduction After the identification of genetic elements in DNA it became apparent that specific cell functions required sophisticated mechanism to regulate gene expression [ 1 ]. This is obtained by modifications of DNA and of histones: methyl residues can be inserted on DNA (cytidine) or on histones (lysine or arginine), while acetyl groups on histones are added or removed to turn genes on or off. The epigenetic machinery is very complex consisting of different protein complexes responsible for the different steps required: by applying a simplification that is certainly inaccurate but useful in practical terms, proteins involved in epigenetic regulation can be divided into writers, erasers and readers. When it was found that these mechanisms may also be responsible for the malignant behaviour of transformed cells [ 2 , 3 ] researchers started to look for specific inhibitors that coul...

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract The dictionary definition of "necrotizing” is causing or undergoing necrosis, a word said to have been first used in 1899. Historically, even before 1899, medical men and even cancer quacks had attempted to cure cancer with drugs. Nowadays, this is being intensified. Therefore, a personal hypothesis is proposed here with direct appeal to the recondite researchers in the fruitful field of drug designing and development. Keywords: Cancer; Necrosis; Drug; Design; Thoracic duct; Research Introduction The Merriam-Webster's Collegiate Dictionary defines "necrotizing" as "causing or undergoing necrosis" [ 1 ]. It went on to indicate that this word was first used in 1899. However, before that year, causing necrosis was broadly the intention of the medical masters faced with ...