Juniper Publishers- Drug Design Open Access Journals

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Recently utilizing nanoemulsion as a vehicle for deliver the drug through transdermal drug delivery has been increased. The purpose of the present study was to develop a nanoemulsion formulation of cyclobenzaprine hydrochloride and characterize for transdermal drug delivery. Aqueous titration method was adopted for various oil-in-water nanoemulsion preparations. The prepared nanoemulsions were characterized for its particle size, polydispersity index, zeta potential, TEM, pH, viscosity, drug content, spread ability and its in-vitro release studies. Drug excipient compatibility study results reveals that the excipient used in the nanoemulsion is having compatibility. Based on its in- vitro release studies formulation F14 showed higher release compared to other formulations. Formulation F14 was converted into Nanoemul gel and characterized. The in-vitro release profile of th...

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract This review pertains to an effort to notify the importance of metal binding of naturally occurring molecules. Metallopharmaceutical science is a huge discipline of multifarious applications. In due course of design of metallic drugs one has to rely upon biological relevance of the compound. Sometimes the target activity is lost into toxicity. Hence, the association of a biomolecule or modified bio-compound coordinated with metallic system is the essence of bioconjugation and is the need of hour. Bio-conjugated metallic complexes are always praised for better action. Some diseases have been exemplified in this review and a comprehensive way of presentation has been established throughout the text. Keywords: Bioconjugation; AD; Diabetes; Cancer; Antioxidant Introduction Bioconjugation is a met...