Juniper Publishers- Drug Design Open Access Journals

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Short Communication An eighty four year old Caucasian male started taking glucosamine for joint health two years previously. He failed to notice that the glucosamine tablets also contained large doses of cholecalciferol, a precursor of vitamin D. According to the label on the container, two tablets each having five times the recommended daily amount (RDA) were to be taken every day. This was in addition to the vitamin D taken in milk at breakfast, and that in half gram calcium tablets taken twice daily and also vitamin D in a multiple vitamin preparation. All together this added up to 6000 international units (IU) of the vitamin taken each day. The RDA for older people is 800 IU. So he was taking 7.5 times the RDA of vitamin D for over a year. When he discovered the overdose, he stopped taking vitamin D except for milk at breakfast. Symptoms noted during vitamin D intoxication were mo...

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Considering the significance of RNA genome in the HIV infection, its release can be forbidden by inhibiting encapsulated Capsid (CA) "core". In this context, design of new molecules that interact with HIV-1 CA assembly was made by conducting 3D-QSAR and Pharmacophore studies on a stockpile of fifty eight molecules. The supramolecular interactions of these inhibitors with the receptors active site amino acids Glu 35, Gly 60, His62, Gln 63, Ala 65, and Val 136 has been characterized using docking studies. The combined five point Pharmacophore hypothesis AHHRR, and 3D-QSAR CoMFA (Comparative molecular field analysis) and CoMSIA (Comparative molecular similarity indices analysis) has shown good statistical partial least square factors. The association of generated 3D-QSAR and PHASE pharmacophore hypothesis has provided structural insights to explore new molecules with enhanced ...