Juniper Publishers- Drug Design Open Access Journals

Organised Surfactant System: Micro Emulsion Authored by  Mayur A Chordiya Advantages of micro emulsion based systems Microemulsions are thermodynamically stable system and the stability allows self-emulsification of the system whose properties are not dependent on the process followed. Microemulsions act as super solvents of drug. The dispersed phase, lipophilic or hydrophilic (oil-in-water, O/W, or water-in-oil, W/O microemulsions) can behave as a potential reservoir of lipophilic or hydrophilic drugs, respectively. The mean diameter of droplets in microemulsions is below 0.22μm; they can be sterilized by filtration. Same microemulsions can carry both lipophilic and hydrophilic drugs. Because of thermodynamic stability, microemulsions are easy to prepare and require no significant energy contribution during preparation. Microemulsions have low viscosity compared to other emulsions. The use of microemulsion as delivery systems can improve the efficacy of a...

Overview on the Applications and Effects of Peptides in the Therapeutic Authored by Mozhdeh Haddadi Peptides and bioactive proteins are detected as new therapeutic molecules with changing biological attributes for potential medical claims. With attention to their practical properties, bioactive peptides may be classified as antimicrobial, antihypertensive, opioid, antioxidative and etc. These peptides play a significant identity in human health. Progress of peptide and protein based therapeutic output for human use is growing continually as they carry on to receive an enhancing ratio of support by (US FDA). Peptide based drugs are a significant series of therapeutic agents but their progress into commercial products is often blocked due to their natural physico-chemical and biological instabilities. In this mini review, we characterize the recent methodologies and condition involved in the peptide and protein in industry in the therapeutic products section. ...

Sepsis Needs Follow-Up Studies in Intensive Care Units- Another Avenue for Transitional Research Authored by Carlota Saldanha Sepsis characteristics were highlight in this mini review in order to call attention for a complex, age- independent, acute disease faced suddenly by the human body under infection or traumatic stimuli. It may follow surgical intervention, traumatic accident or exposure to an infectious agent. Timely diagnosis and accurate stratification of the severity of sepsis are needed to understand the molecular mechanisms involved in this pathophysiology and reduce mortality. In order to obtain these achievements follow-up studies need to be conducted in intensive care units under translational research. To Read More..  Full Text  in  Novel Approaches in Drug Designing & Development  in  Juniper Publishers

Should Nano-particles Be Used to Cross Blood Brain Barrier to Deliver Drugs to Neurodegenerative Diseases? Treating diseases of central nervous system by delivering therapeutic agents faces a big problem of crossing blood brain barrier. For combating this challenge various types of nano particles such as polymeric nano particles, nano metals, carbon quantum dots are being used with reasonable success in crossing the BBB and enhancing the drug efficacy. However, certain aftermath negative impact of use of nanotechnology for drug delivery to brain has not been considered. In this opinion/short-communication attention has been paid to the need of considering various aspects that may cause damage to brain. To Read More.. Full Text  in  Novel Approaches in Drug Designing & Development  in  Juniper Publishers

Prevalence of Crimean-Congo hemorrhagic fever Virus in Pakistan Authored by  Sobia Ahsan Halim Crimean Congo virus that causes hemorrhagic fever belongs to Bunyaviridea family [1] and genus Nairoviridea [2]. First case of this disease was inspected in Tajisktan in 12th century [3] however this disease gained more attention in 1944 when about 200 military officers of Soviet Union died of this infectious disease at the place of Crimea so named as Crimean Congo hemorrhagic fever. Its etiology was studied by inducing fever in psychiatric patients by inoculating them with virus obtained from the blood of CCHF patients. Chumkov and his colleagues first time isolated a prototype of this virus in 1967 in Moscow [4]. This virus has wide geographical distribution and found across middle east, china, southern Europe, Africa and various areas of Asia. To Read More.. Full text  in  Novel Approaches in Drug Designing & Development in Juniper Publishers

Lumbar Intervertebral Disc Calcification: A Case Report Authored by  Umit Eroglu Intervertebral disc calcification is an uncommon cause of spinal pain and really rare in lumbar disc levels. The certain etiology still remains uncertain. Most of cases are asymptomatic and are diagnosed incidentally in routine scanning or during evaluation of non-specific clinical complaints. A 63-year-old male presented with waist and both legs pain. There was no definite history of trauma or infection. Imaging of the lumbar spine showed calcification of the intervertebral disc at L1-2 level. The patient was kept on medical therapy. The complaints showed near-complete resolution on 3-month follow-up. To read more. PHP in  Novel Approaches in Drug Designing & Development in Juniper Publishers

Modified Starch and Its Potentials as Excipient in Pharmaceutical formulations Authored by  Khalid Garba Mohammed Despite its vast commercial value, native starch has some inherent weaknesses when it comes to pharmaceutical application, to mention few include; poor compressibility, low flow ability values and often drug/excipient compatibility problems. In this review, some potentials of modified starch with particular emphasis on their improved functionalities and applicability in pharmaceutical formulations were discussed. Basic requirements for pharmaceutical excipients and various modification methods for starch i.e chemical modification, physical and biotechnological methods were highlighted.Pharmaceutical applications of modified starches as tablet super disintegrant, sustained/controlled release polymer, plasma volume expanders and as directly compressible excipient in tablet formulations have been cited. To read more. PHP in  Novel Approaches in Dr...