Avasimibe and Sirt 1 Activators Reverse NAFLD and Obesity|Drug Designing & Development|Juniper Publishers



Authored by Ian James Martins in Juniper Publishers|Novel Approaches in Drug Designing & Development

In epidemiological studies human obesity is clearly associated with the increased risk for atherosclerosis contributing to the early onset of coronary artery disease and diabetes. Visceral obesity in particular increases the risk of atherosclerosis owing to both insulin resistance and dyslipoproteinemia. Risk factors for atherosclerosis that could be exacerbated by obesity include hypertension and hyper lipidemia particularly hyper triglyceridemia which are risk factors for Alzheimer’s disease. The susceptibility of humans to obesity is far higher compared with other species and in man favours the deposition of fat [1]. 

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