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Lupine Publishers: Lupine Publishers | Seismic Strengthening of Mason...: Lupine Publishers | Trends in Civil Engineering and its Architecture The experimental study on evaluation of seismic resistance of ...

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Bioconjugation among Metallopharmaceuticals: A Review-Juniper Publishers

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  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract This review pertains to an effort to notify the importance of metal binding of naturally occurring molecules. Metallopharmaceutical science is a huge discipline of multifarious applications. In due course of design of metallic drugs one has to rely upon biological relevance of the compound. Sometimes the target activity is lost into toxicity. Hence, the association of a biomolecule or modified bio-compound coordinated with metallic system is the essence of bioconjugation and is the need of hour. Bio-conjugated metallic complexes are always praised for better action. Some diseases have been exemplified in this review and a comprehensive way of presentation has been established throughout the text. Keywords: Bioconjugation; AD; Diabetes; Cancer; Antioxidant Introduction Bioconjugation is a met...
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Bioactive Compound Produced from Actinomycetes- Streptomyces-Juniper Publishers

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Islet Cell Transplantation for Treating Type 1 Diabetes: The Bright Future of Drug Designing and Development-Juniper Publishers

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  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Short Communication The revolutionary process of islet transplantation for treating type 1 diabetes has been limited by the high level of graft failure. The process of islet isolation alone has been shown to negatively impact islet survival and function in vivo. In addition, insults mediated by the instant blood-mediated inflammatory reaction, hypoxia, ischemia and immune response significantly impact the islet allograft post transplantation [ 1 , 2 ]. Moreover, the immune response to alloantigens and recurrence of autoimmunity contribute to pancreatic islet transplant dysfunction [ 3 ]. Several approaches are being developed and tried to overcome this serious problem and novel drug designing is heavily involved with promising results and bright rewards. Some of these approaches are being discussed briefly in this commentary. Regenerating islet-derived protein 3 alpha; a pancreatic se...
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