Juniper Publishers- Drug Design Open Access Journals

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract This research deals with formulation of compression coated tablet of 5-Aminosalicylic acid and further evaluated for colon targeting ability. Drug 5-aminosalicylic acid is degraded in stomach in the presence of gastric pH so colon targeting is best way to achieve therapeutic effect. Initially core tablet of drug was prepared using microcrystalline cellulose as diluents and further it was compression coated using various concentration of Prunus amygdalus gum. Prepared tablets were evaluated for various physical and mechanical parameters such as hardness, size and shape, friability and weight variation. To evaluate drug release ability of formulated tablet in to colon, In vitro drug release study was carried out in 0.1 N HCl and phosphate buffer pH 7.4. Formulated tablets were found to be round in shape with 13.436±0.020 to 13.482±0.017mm diameter. Hardness of tablets was found to be 1...

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Erythrocytes are powerful components of blood flow designed to scavenger or deliver nitic oxide (NO) and oxygen to all cells in the body and transport carbon dioxide from them to the lungs. Blood components started to be quantified and erythrocyte blood shapes used as diagnostic and prognostic tools in clinical practice. Erythrocytes have hemorheological, hemostatic and pro or anti-inflammatory properties enlarging their physiological implications in health and disease. As blood component the erythrocytes establish interaction with others white blood cells, platelets, plasma lipoproteins and vascular endothelial cells. The aim of this mini review is highlight the signaling pathway of nitric oxide in which some steps explain the efficacy of some therapeutic drugs already used and could point new targets for further application in inflammatory vascular diseases Keywords: Eryth...