Juniper Publishers- Drug Design Open Access Journals

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Glycolic acid is used to improve skin aging and in combination with nutraceuticals like vitamins C or E, it may provide synergestic effect for skin protection. Liposome formulation were prepared by film hydration method and studied for different test parameters like zeta potential, particle size, entrapment efficiency and in vitro release studies. The particle size and zeta potential were found to be in range of 200-900 nm and ±14mv to ±29mv. The entrapment efficiency was found to be between 16-76% and in vitro drug release was in controlled manner. Liposome formulation containing vitamins E and C, and cholesterol was found to be most optimum and effective. Hence, Liposomes composed of vitamin E and vitamin C can be used as an alternative to cosmetic applications. Keywords: Liposomes; Glycolic acid; Vitamin C; Vitamin E; Cosmetics ...

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Drugs aesign is usually focusea on affinity to binaing sites. However, such an approach, which is meaningful ana promising, shoula not neglect the contribution of metabolism to the efficacy ana tolerability of a arug. Metabolism is often primarily regaraea as a source of arug elimination. On the other hand, metabolites can have their own pharmacological properties, which may be highly undesired, but, in other cases, can be favorable. In this short review, examples are given for oxiaotoxicity of metabolites, incluaing the possibility of organic reaox cycling, for non-enzymatic formation of metabolites with unaesirea properties, for unexpectea changes in lipophilicity, ana for presumably favorable properties of certain metabolites. The relationship of molecular complexity of a arug to the number of metabolites is aaaressea. The necessity for not neglecting the possible toxicity of...