Juniper Publishers- Drug Design Open Access Journals

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Functionally selective ligands (also known as biased ligands) of dopamine D2 receptors have been considered as not only valuable tools for dissecting the roles of D2-mediated G protein-dependent and independent signaling pathways, but also better antipsychotic drug candidates for neurological and psychiatric disorders including schizophrenia. Consequently, functionally selective D2R ligands have also been increasingly pursued by the biomedical community as promising antipsychotic therapeutics with improved efficacy and reduced side effects compared with unbiased ligands. This review will discuss the recent development in the discovery of functional selective D2R ligands Figure 1 . Introduction Schizophrenia is a chronic and severe mental disorder characterized by abnormal social behavior and failure to und...

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Short Communication An eighty four year old Caucasian male started taking glucosamine for joint health two years previously. He failed to notice that the glucosamine tablets also contained large doses of cholecalciferol, a precursor of vitamin D. According to the label on the container, two tablets each having five times the recommended daily amount (RDA) were to be taken every day. This was in addition to the vitamin D taken in milk at breakfast, and that in half gram calcium tablets taken twice daily and also vitamin D in a multiple vitamin preparation. All together this added up to 6000 international units (IU) of the vitamin taken each day. The RDA for older people is 800 IU. So he was taking 7.5 times the RDA of vitamin D for over a year. When he discovered the overdose, he stopped taking vitamin D except for milk at breakfast. Symptoms noted during vitamin D intoxication were mo...