Juniper Publishers- Drug Design Open Access Journals

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Considering the significance of RNA genome in the HIV infection, its release can be forbidden by inhibiting encapsulated Capsid (CA) "core". In this context, design of new molecules that interact with HIV-1 CA assembly was made by conducting 3D-QSAR and Pharmacophore studies on a stockpile of fifty eight molecules. The supramolecular interactions of these inhibitors with the receptors active site amino acids Glu 35, Gly 60, His62, Gln 63, Ala 65, and Val 136 has been characterized using docking studies. The combined five point Pharmacophore hypothesis AHHRR, and 3D-QSAR CoMFA (Comparative molecular field analysis) and CoMSIA (Comparative molecular similarity indices analysis) has shown good statistical partial least square factors. The association of generated 3D-QSAR and PHASE pharmacophore hypothesis has provided structural insights to explore new molecules with enhanced ...

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Peroxisome proliferator activated receptor a (PPARα) is ligand-activated transcriptional factor receptor belonging to nuclear receptors family. It plays a key role in lipid metabolism and glucose homeostasis and it is important in the prevention and treatment of metabolic diseases. PPARα has also a protective effects against brain cell death attributed to its anti-inflammatory and antioxidant properties. In the present work, we discuss the PPAR involvement in neurodegenerative pathologies and its potential as therapeutic target for these diseases. Keywords: Alzheimers disease; Parkinsons disease; Neuroprotection Abbreviations: PPARs: Peroxisome Proliferator Activated Receptors; RXR: Retinoid X-Receptor; SARs: Structure Activity Relationships; PEA: Palmitoyl Ethanol Amide; LPS: Lipo Poly Saccharide. Mini Review Peroxis...