Juniper Publishers- Drug Design Open Access Journals

 Novel Approaches in Drug Designing & Development - Juniper publishers Abstract Cephalosporins representing a wide variety of β-lactam antibiotics. Cephalosporins have some desirable features, including a convenience of administration, a reasonably broad spectrum of efficacy and a low incidence of toxicity. A descriptive cross-sectional study on the usage of cephalosporin for the treatment of respiratory tract infections (RTI) and urinary tract infections (UTI) was conducted at Ibnsinaa and Alshaab Hospitals in Khartoum state. The data were acquired via questionnaires sent to doctors and community pharmacists, as well as 48 patient files with UTI and RTI diagnoses. SPSS was used to examine the data. The study’s findings indicated that 90% of physicians and pharmacists do not follow cephalosporin prescription and dispensing recommendations. 73% of cephalosporins (3rd generation) are used to treat UTI, whereas 54% of cephalosporins (2nd generation) are used to treat RTI. At concl...

 Novel Approaches in Drug Designing & Development - Juniper publishers Abstract The coronavirus (COVID-19) pandemic became one of the most important disease problem across the globe for last few years since there is no recommended efficacious drugs in the market. So, there is an urgent need for efficient drugs to treat this disease in the near future. In the present study, molecular docking analyses of selective cyclooxygenase-2 inhibitor drugs (Celecoxib, Rofecoxib, Valdecoxib, Lumiracoxib, Parecoxib, Etoricoxib, and Firocoxib) were performed against the therapeutic target proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) enzyme into the catalytic active site. On the other hand, these drugs were compared with standard drugs such as Favipiravir, Chloroquine and Hydroxychloroquine to understand the binding sites and find the best poses. The results revealed that all the selective cyclooxygenase-2 inhibitor drugs (except Lumiracoxib) sh...

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Functionally selective ligands (also known as biased ligands) of dopamine D2 receptors have been considered as not only valuable tools for dissecting the roles of D2-mediated G protein-dependent and independent signaling pathways, but also better antipsychotic drug candidates for neurological and psychiatric disorders including schizophrenia. Consequently, functionally selective D2R ligands have also been increasingly pursued by the biomedical community as promising antipsychotic therapeutics with improved efficacy and reduced side effects compared with unbiased ligands. This review will discuss the recent development in the discovery of functional selective D2R ligands Figure 1 . Introduction Schizophrenia is a chronic and severe mental disorder characterized by abnormal social behavior and failure to und...