Juniper Publishers wishes Happy Easter to you and your family members

         


Juniper Publishers







Comments

Post a Comment

Popular posts from this blog

Erythrocyte as a Therapeutic Target-Juniper Publishers

Image
  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Erythrocytes are powerful components of blood flow designed to scavenger or deliver nitic oxide (NO) and oxygen to all cells in the body and transport carbon dioxide from them to the lungs. Blood components started to be quantified and erythrocyte blood shapes used as diagnostic and prognostic tools in clinical practice. Erythrocytes have hemorheological, hemostatic and pro or anti-inflammatory properties enlarging their physiological implications in health and disease. As blood component the erythrocytes establish interaction with others white blood cells, platelets, plasma lipoproteins and vascular endothelial cells. The aim of this mini review is highlight the signaling pathway of nitric oxide in which some steps explain the efficacy of some therapeutic drugs already used and could point new targets for further application in inflammatory vascular diseases Keywords: Eryth...
Read more

Considering Drug Metabolism and Molecular Complexity in Drug Design-Juniper Publishers

Image
  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract Drugs aesign is usually focusea on affinity to binaing sites. However, such an approach, which is meaningful ana promising, shoula not neglect the contribution of metabolism to the efficacy ana tolerability of a arug. Metabolism is often primarily regaraea as a source of arug elimination. On the other hand, metabolites can have their own pharmacological properties, which may be highly undesired, but, in other cases, can be favorable. In this short review, examples are given for oxiaotoxicity of metabolites, incluaing the possibility of organic reaox cycling, for non-enzymatic formation of metabolites with unaesirea properties, for unexpectea changes in lipophilicity, ana for presumably favorable properties of certain metabolites. The relationship of molecular complexity of a arug to the number of metabolites is aaaressea. The necessity for not neglecting the possible toxicity of...
Read more

Avasimibe and Sirt 1 Activators Reverse NAFLD and Obesity-Juniper Publishers

Image
  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Opinion In epidemiological studies human obesity is clearly associated with the increased risk for atherosclerosis contributing to the early onset of coronary artery disease and diabetes. Visceral obesity in particular increases the risk of atherosclerosis owing to both insulin resistance and dyslipoproteinemia. Risk factors for atherosclerosis that could be exacerbated by obesity include hypertension and hyper lipidemia particularly hyper triglyceridemia which are risk factors for Alzheimer’s disease. The susceptibility of humans to obesity is far higher compared with other species and in man favours the deposition of fat [1]. Amongst mammals humans have been reported to have the highest level of fatness than any other species and genes and environmental factors predispose humans to obesity [2]. Novel research provides information for anti-aging genes with connections between appeti...
Read more