Juniper Publishers- Drug Design Open Access Journals

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract The aim of present work was to prepare the composites of ionic polymer chitosan with non ionic polymer guar gum and then to evaluate it as an excipient for the fast disintegrating drug delivery systems. Chitosan gel (5%) was prepared using acetic acid solution (2%) while 5% guar gum solution was prepared using deionised water. Composite was prepared by mixing both polymers in same proportion at regulated temperature. The dried and sieved composite was characterized for its micromeritic properties, flow behaviour, swelling behaviour and surface characteristics. Six batches of tablets Were prepared with composites in different ratios viz. 5, 10, 20, 30, 40 and 50% of total tablet weight, using phenytoin sodium as model drug. These tablets were evaluated for hardness, friability, weight variation, in-vitro disintegration time, in-vitro release characteristics and stability study...

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract The present study a new strategy for the synthesis of most potent nitrogen heterocycles i.e., triazinane-2-thiones and oxadiazinanes-4- thiones (3-4) were efficiently synthesized by cyclic condensation based on classical Mannich amino methylation of N, N' unsymmetrical Thio ureas. The synthesized compounds have been characterized by analytical and spectral (IR, 1HNMR and Mass) data. Keywords: Synthesis; Characterization; Triazinane-2-thione; Benzimidazole Introduction Demand for higher efficiency, economy and selectivity in the synthesis of novel molecular scaffolds drives organic chemistry, particularly nitrogen-containing molecules has been of longstanding interest to organic chemists due to their great importance in chemistry and biology [ 1 ]. Many of these heterocyclic compounds exhi...