Juniper Publishers: Juniper Publishers - Spreading Quality of Latest S...

Juniper Publishers: Juniper Publishers - Spreading Quality of Latest S...: Juniper Publishers Inc . is established with the aim of spreading quality scientific information to the research community throughout the ...

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Bioactive Compound Produced from Actinomycetes- Streptomyces-Juniper Publishers

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  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract The beginning of antibiotic-resistance among the bacteria is really unavoidable. Over the last 60 years, bacteria and, in particular, those pathogenic for humans have evolved toward anti-microbial drug resistance. For the treatment of infectious diseases antibiotics like penicillin and erythromycin are used but now these antibiotics become less effective because bacteria have become more resistant to such antibiotics. The development of new antimicrobial agents is an urgent medical need. Natural products are important sources of lead antimicrobial agents. Actinomycetes are soil dwelling and Gram positive bacteria and industrially wide range of bioactive secondary metabolites producers, including many antibiotics. More than75% of antibiotics are sourced from the genus Streptomyces. This review article focuses on microbial secondary metabolites from Streptomyces as new drugs to f...
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Modelling of Drug Release from a Polymer Matrix System-Juniper Publishers

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  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract A drug release model is proposed to predict the behaviour of an oral drug tablet as it traverses the gastrointestinal (GI) tract. The model predicts the rate of change of tablet dimensions. The effect of polymer degradation rate on the tablet dissolution time and drug release kinetics is analyzed. The total tablet dissolution time decreases with increase in the polymer degradation rate constant ( k d ). A simpler second model (power law) is also offered to describe the relationship between tablet dissolution time and k d . The model predicts initial burst release of the drug followed by nearly constant release. The time of burst release and the amount of drug undergoing burst release decreases with increases in the k d . Keywords: Drug release model; Drug diffusion; Polymer matrix swelling; Polymer dissolution; Release kinetics Abbrevations: HPMC: Hydroxy Propyl M...
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Bioconjugation among Metallopharmaceuticals: A Review-Juniper Publishers

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  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT Abstract This review pertains to an effort to notify the importance of metal binding of naturally occurring molecules. Metallopharmaceutical science is a huge discipline of multifarious applications. In due course of design of metallic drugs one has to rely upon biological relevance of the compound. Sometimes the target activity is lost into toxicity. Hence, the association of a biomolecule or modified bio-compound coordinated with metallic system is the essence of bioconjugation and is the need of hour. Bio-conjugated metallic complexes are always praised for better action. Some diseases have been exemplified in this review and a comprehensive way of presentation has been established throughout the text. Keywords: Bioconjugation; AD; Diabetes; Cancer; Antioxidant Introduction Bioconjugation is a met...
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